反応式
[CH3:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[NH2:10][OH:11].O.C(Cl)Cl.CO>CCO>[OH:11][N:10]=[C:4]([NH2:5])[C:3]1[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=1[CH3:1]参加物
6
反応条件
- 温度
- 70 °C
実験手順
A mixture of 2-methyl-benzonitrile (0.950 mL, 8 mmol), hydroxylamine 50% in water (1.6 mL, 24 mmol) and EtOH (8 mL) was heated at 70° C. for 48 h. TLC analysis (DCM/MeOH: 97/3 as eluent) indicates the completion of the reaction. The solvent was removed under reduced pressure to afford 1.2 g of N′-hydroxy-2-methylbenzamidine (Yield: 100%) as a white powder (M.P.=147-148.5° C.). which can be used without further purification.
後処理
- customthe completion of the reaction
- customThe solvent was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-10ac7e740fc04206bbb1be61000b08d5
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08883826B2
関連ノート
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