2-Bromopyridine → 5-(Pyridin-2-yl)pent-4-yn-1-ol

HRID 334633ノート

反応式

HRID 334633 の反応式
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:8]([OH:13])[CH2:9][CH2:10][C:11]#[CH:12]>>[N:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[C:12]#[C:11][CH2:10][CH2:9][CH2:8][OH:13]

参加物

3

反応物 2

HCID 79732-BromopyridineHCID 793464-Pentyn-1-ol

生成物 1

HCID 109973535-(Pyridin-2-yl)pent-4-yn-1-ol収率 88%

実験手順

The title compound was prepared in accordance with the general method of Example 1, from 2-bromopyridine (4.46 g, 28.2 mmol) and pent-4-yn-1-ol (2.50 g, 29.7 mmol). Reaction time: 14 hours. The crude residue was purified by flash chromatography (DCM/MeOH 97:3) to yield 4.00 g (24.8 mmol, 88%) of 5-pyridin-2-yl-pent-4-yn-1-ol as a brown oil.

後処理

  1. customReaction time
  2. custom14 hours
  3. customThe crude residue was purified by flash chromatography (DCM/MeOH 97:3)

出典と根拠

ORDレコード
ord-98edddd21dcc4395a858f90956eb11f8
出典データセット
uspto-grants-2014_11
特許番号
US08883826B2

反応ノート

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