1-Hydroxy-2-naphthoic acid → 4-Bromo-1-hydroxynaphthalene-2-carboxylic acid

HRID 335049

反応式

HRID 335049 の反応式
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]([OH:14])=[O:13].[Br:15]Br>C(O)(=O)C>[Br:15][C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([OH:1])=[C:3]([C:12]([OH:14])=[O:13])[CH:4]=1

参加物

4

反応物 2

HCID 68441-Hydroxy-2-naphthoic acidHCID 24408Bromine

生成物 1

HCID 2893934-Bromo-1-hydroxynaphthalene-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a solution of 1-hydroxy-2-naphthoic acid (10.2 g, 53.9 mmol) in 100 mL of acetic acid was added bromine (6.60 mL, 53.9 mmol) dropwise. After 72 hours, the reaction was filtered and the filter cake was washed with acetic acid (40 mL) and hexanes (150 mL) to provide 4-bromo-1-hydroxy-2-naphthoic acid that gave a proton NMR spectra consistent with theory.

後処理

  1. filtrationthe reaction was filtered
  2. washthe filter cake was washed with acetic acid (40 mL) and hexanes (150 mL)

出典と根拠

ORDレコード
ord-da2eefd0dd944cde9cff264726e045a2
出典データセット
uspto-grants-2014_11
特許番号
US08883850B2

関連ノート

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