Benzoyl Peroxide → 2-(1-Bromoethyl)pyridine
反応式
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1)[CH3:2].C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.[Br:27]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Br:27][CH:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1)[CH3:2]参加物
5
実験手順
2-Ethylpyridine (20.0 g, 186.65 mmol) was placed in carbon tetrachloride (830 mL) and benzoyl peroxide (4.5211 g, 18.665 mmol) and 1-bromopyrrolidine-2,5-dione (33.221 g, 186.65 mmol) were added. The reaction mixture was heated to reflux for 18 hours, then cooled to room temperature and filtered. The filtrate was concentrated and the residue was purified over a plug of silica to give 2-(1-bromoethyl)pyridine (17.312 g, 49.9%). 1H NMR (CDCl3) δ 8.58 (d, 1H), 7.69 (td, 1H), 7.76 (d, 1H), 7.20 (dd, 1H), 5.24 (q, 1H), 2.08 (d, 3H)
後処理
- temperatureThe reaction mixture was heated
- temperatureto reflux for 18 hours
- filtrationfiltered
- concentrationThe filtrate was concentrated
- customthe residue was purified over a plug of silica
出典と根拠
- ORDレコード
- ord-b6cd741540ee4b83a966361d0022c63f
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08883828B2
反応ノート
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