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HRID 335298作成日：2026年10月26日

3-Fluoro-4-(methoxycarbonyl)benzeneboronic acid → 4-(3-(5-(2-(2,6-cis-Dimethylpiperidin-1-yl)ethylcarbamoyl)-2-fluorophenyl carbamoyl)imidazo[1,2-a]pyridin-7-yl)-2-fluorobenzoic Acid

https://huagongshe.com/reaction/335298

反応式

関与物質

役割名称HCID仕込み量
反応物3-Fluoro-4-(methoxycarbonyl)benzeneboronic acidHCID 2782818—
反応物7-bromo-N-(5-(2-(2,6-cis-dimethylpiperidin-1-yl)ethylcarbamoyl)-2-fluorophenyl)imidazo[1,2-a]pyridine-3-carboxamideHCID 71283219—
生成物4-(3-(5-(2-(2,6-cis-Dimethylpiperidin-1-yl)ethylcarbamoyl)-2-fluorophenyl carbamoyl)imidazo[1,2-a]pyridin-7-yl)-2-fluorobenzoic AcidHCID 71283338—

反応手順

The title compound was prepared from 7-bromo-N-(5-(2-(2,6-cis-dimethylpiperidin-1-yl)ethylcarbamoyl)-2-fluorophenyl)imidazo[1,2-a]pyridine-3-carboxamide (Intermediate 4C) and 3-fluoro-4-(methoxycarbonyl)phenylboronic acid analogously to Example 1.20;

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08883819B2
出典データセットuspto-grants-2014_11
ORD IDord-517ae9f117664e2baf116881e32b171e
出典メモuspto-grants-2014_11