Dimethylformamide → Imidazo[1,2-a]pyridine-3-carbonyl Chloride

HRID 335333ノート

反応式

HRID 335333 の反応式
[N:1]1[CH:2]=[C:3]([C:10]([OH:12])=O)[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.C(Cl)(=O)C([Cl:16])=O.CN(C=O)C>C(Cl)Cl>[N:1]1[CH:2]=[C:3]([C:10]([Cl:16])=[O:12])[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 73142Imidazo(1,2-a)pyridine-3-carboxylic acid

生成物 1

HCID 74890117Imidazo[1,2-a]pyridine-3-carbonyl Chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A suspension of imidazo[1,2-a]pyridine-3-carboxylic acid (5.270 g, 32.5 mmol) in DCM (200 ml) was treated with oxalyl chloride (3.13 ml, 35.8 mmol) followed by the addition of DMF (0.252 ml, 3.25 mmol). The reaction mixture was stirred at RT overnight. The solvent was removed in vacuo to afford the title compound as a hydrochloride salt;

後処理

  1. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-122103a473254fb99f822a83836a206f
出典データセット
uspto-grants-2014_11
特許番号
US08883819B2

反応ノート

読み込み中…