Sodium Hydroxide → 6-Methyl-5-(6-(1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyridine-3-carboxamido)nicotinic Acid
反応式
[CH3:1][C:2]1[C:10]([NH:11][C:12]([C:14]2[CH:15]=[N:16][N:17]3[CH:22]=[C:21](C4C=NN(C)C=4)[CH:20]=[CH:19][C:18]=23)=[O:13])=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.BrC1C=CN2[C:36]([C:39]([NH:41]C3C(C)=NC=C(C=3)C(OC)=O)=O)=[CH:37][N:38]=[C:32]2C=1.CN1C(B2OC(C)(C)C(C)(C)O2)=CC=N1.[OH-].[Na+]>>[CH3:1][C:2]1[C:10]([NH:11][C:12]([C:14]2[CH:15]=[N:16][N:17]3[CH:22]=[C:21]([C:37]4[N:38]([CH3:32])[N:41]=[CH:39][CH:36]=4)[CH:20]=[CH:19][C:18]=23)=[O:13])=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1参加物
5
反応物 4
生成物 1
実験手順
The title compound was prepared analogously to 6-methyl-5-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamido)nicotinic acid (Example 9.0 step 2) from Intermediate 1C and 1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole followed hydrolysis of the resulting methyl ester using sodium hydroxide;
出典と根拠
- ORDレコード
- ord-34fd010f8bc54a47a5e1bf413d84d817
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08883819B2
反応ノート
読み込み中…