1-[(4-fluorophenyl)methyl]-4-methoxy-2-methyl-1H-indole → 1-[(4-fluorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[C:17]3[C:12](=[C:13]([O:18]C)[CH:14]=[CH:15][CH:16]=3)[CH:11]=[C:10]2[CH3:20])=[CH:4][CH:3]=1.B(Br)(Br)Br.C(Cl)Cl>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][N:9]2[C:17]3[C:12](=[C:13]([OH:18])[CH:14]=[CH:15][CH:16]=3)[CH:11]=[C:10]2[CH3:20])=[CH:6][CH:7]=1参加物
3
実験手順
By the method used in Example 1, Part D, 1.1 g (4.1 mmol) of 1-[(4-fluorophenyl)methyl]-4-methoxy-2-methyl-1H-indole was O-demethylated by treating it with 16.4 mL of 1M BBr3 /CH2Cl2 to give 881 mg (84% yield) of crude 1-[(4-fluorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole.
出典と根拠
- ORDレコード
- ord-858e366b919f470e923529fff24917ea
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05733923
反応ノート
読み込み中…