Chloroacetyl chloride → N-benzyl-2-chloro-N-methylacetamide

HRID 335540

反応式

HRID 335540 の反応式
[CH3:1][NH:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[Cl:10][CH2:11][C:12](Cl)=[O:13]>CCOC(C)=O.C([O-])(O)=O.[Na+]>[CH2:3]([N:2]([CH3:1])[C:12](=[O:13])[CH2:11][Cl:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参加物

5

反応物 2

HCID 6577Chloroacetyl chlorideHCID 7669N-Methylbenzylamine

生成物 1

HCID 4639192N-benzyl-2-chloro-N-methylacetamide収率 63.2%

試薬・触媒・溶媒 2

HCID 8857Ethyl Acetate溶媒HCID 516892Sodium Bicarbonate溶媒

実験手順

To a vigorously stirred suspension of N-methylbenzylamine (0.260 mL, 2 mmol) in EtOAc (3 mL) and 3 mL of saturated NaHCO3 solution was added chloroacetyl chloride (0.160 mL, 2 mmol). Effervescence was observed. Once gas production had ceased, the reaction mixture was diluted with hexanes (10 mL). The phases were separated and the organic phase was washed with brine (5 mL), dried and concentrated to yield ˜0.250 g of the title compound as an oil. The crude material was used in the subsequent step without further purification.

後処理

  1. customThe phases were separated
  2. washthe organic phase was washed with brine (5 mL)
  3. customdried
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-530428ae848045debcd1e14d8f8416a2
出典データセット
uspto-grants-2014_11
特許番号
US08884034B2

関連ノート

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