1-Naphthalen-1-ylpropan-1-one → 2-Bromo-1'-propionaphthone

HRID 33557ノート

反応式

HRID 33557 の反応式
[C:1]1([C:11](=[O:14])[CH2:12][CH3:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[Br-:15].[Br-].[Br-].C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1>O1CCCC1>[Br:15][CH:12]([CH3:13])[C:11]([C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1)=[O:14]

参加物

4

反応物 2

HCID 2311591-Naphthalen-1-ylpropan-1-oneHCID 17977687Phenyltrimethylammonium bromide dibromide

生成物 1

HCID 2311612-Bromo-1'-propionaphthone収率 175.6%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 1-(naphth-1-yl)-1-propanone (4.0 g) in anhydrous tetrahydrofuran (50 ml) was added phenyltrimethylammonium tribromide (8.0 g). The resulting mixture was stirred overnight at room temperature then partitioned between petroleum ether and aqueous sodium carbonate solution. The organic layer was separated, washed with water, brine, dried with sodium sulphate, filtered and evaporated in vacuo to yield crude 2-bromo-1-(naphth-1-yl)-1-propanone (5.7 g).

後処理

  1. customthen partitioned between petroleum ether and aqueous sodium carbonate solution
  2. customThe organic layer was separated
  3. washwashed with water, brine
  4. dry with materialdried with sodium sulphate
  5. filtrationfiltered
  6. customevaporated in vacuo

出典と根拠

ORDレコード
ord-6f9b7a4872db46e69235876df70a9231
出典データセット
uspto-grants-2008_09
特許番号
US07429607B2

反応ノート

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