Hydrochloric Acid → HCID 66848946、化合物
反応式
Cl.[I:2][C:3]1([CH2:6][C@@H:7]([CH2:16][O:17][Si](C)(C)C(C)(C)C)[O:8][Si](C)(C)C(C)(C)C)[CH2:5][CH2:4]1>C1COCC1>[I:2][C:3]1([CH2:6][C@H:7]([OH:8])[CH2:16][OH:17])[CH2:5][CH2:4]1参加物
4
実験手順
Aqueous HCl solution is added to a solution of (S)-5-((1-iodocyclopropyl)methyl)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecane in THF at 0° C. The mixture is slowly warmed to room temperature and stirred for 24 hours. The reaction is quenched by addition of aqueous NaHCO3 solution, extracted with ethyl acetate, and the combined organic layers washed with brine, dried (MgSO4) and concentrated under reduced pressure to provide (S)-3-(1-iodocyclopropyl)propane-1,2-diol (0.598 mmol).
後処理
- customThe reaction is quenched by addition of aqueous NaHCO3 solution
- extractionextracted with ethyl acetate
- washthe combined organic layers washed with brine
- dry with materialdried (MgSO4)
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-cc14022454a04c6095b610e1c25ec578
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08884058B2
反応ノート
読み込み中…