Diethyl Ether → HCID 50914394、化合物

反応式

[C:1]([Li])([CH3:4])([CH3:3])[CH3:2].[CH3:6][C:7]1([CH3:12])[O:11][CH2:10][CH2:9][O:8]1.[S:13]([Cl:16])(Cl)=[O:14].CC[O:19]CC>>[CH3:6][C:7]1([CH3:12])[O:11][C@@H:10]([CH2:2][C:1]2([S:13]([Cl:16])(=[O:14])=[O:19])[CH2:4][CH2:3]2)[CH2:9][O:8]1

参加物

反応物 4

HCID 3283Diethyl Ether2 回

HCID 24386Thionyl Chloride

HCID 762092,2-Dimethyl-1,3-dioxolane

HCID 178418306HCID 178418306、化合物

生成物 1

HCID 50914394HCID 50914394、化合物

反応条件

温度: -78 °C

実験手順

tert-Butyl lithium (2 eq) is added to a solution of (S)-4-(1-iodocyclopropyl)methyl)-2,2-dimethyl-1,3-dioxolane (1 eq) in ether at −78° C. and the mixture stirred at −78° C. for 30 mins. A solution of thionyl chloride in ether is added, the mixture warmed to room temperature and concentrated under reduced pressure. The residue is dissolved in chloroform, filtered and dried under reduced pressure.