Bromine → 2-Amino-5-bromo-3-fluorobenzoic acid hydrobromide

HRID 335876

反応式

HRID 335876 の反応式
[Br:1]Br.[NH2:3][C:4]1[C:12]([F:13])=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]>C(Cl)(Cl)Cl>[BrH:1].[NH2:3][C:4]1[C:12]([F:13])=[CH:11][C:10]([Br:1])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

参加物

4

反応物 2

HCID 24408BromineHCID 5864082-Amino-3-fluorobenzoic acid

生成物 1

HCID 673836892-Amino-5-bromo-3-fluorobenzoic acid hydrobromide

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

Bromine (3.65 mL, 70.9 mmol) in Chloroform (250 mL) was added dropwise via an addition funnel to a suspension of 2-amino-3-fluorobenzoic acid (10 g, 64.5 mmol) in chloroform (400 mL) at RT. The solution was stirred for 12 hours at which point the resulting slurry was filtered. The solid was washed well with CH2Cl2 and dried under a stream of nitrogen to afford 2-amino-5-bromo-3-fluorobenzoic acid HBr.

後処理

  1. filtrationwas filtered
  2. washThe solid was washed well with CH2Cl2
  3. customdried under a stream of nitrogen

出典と根拠

ORDレコード
ord-61abd4bdca784578aa19294a8726b651
出典データセット
uspto-grants-2014_11
特許番号
US08883782B2

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