18-Crown-6 → (S)-2-fluoro-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine

反応式

C1OCCOCCOCCOCCOCCOC1.[F-].[K+].[F:21][C:22]1[N:27]=[C:26]2[O:28][C:29]3[C:34]([C@@:35]4([CH2:39][O:38][C:37]([NH2:40])=[N:36]4)[C:25]2=[CH:24][C:23]=1I)=[CH:33][C:32]([C:41]1[C:42]([F:47])=[N:43][CH:44]=[CH:45][CH:46]=1)=[CH:31][CH:30]=3.C[Si](C)(C)[C:51]#[C:52][C:53]1([CH3:57])[CH2:56][O:55][CH2:54]1>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Cu]I.CN(C=O)C>[F:21][C:22]1[N:27]=[C:26]2[O:28][C:29]3[C:34]([C@@:35]4([CH2:39][O:38][C:37]([NH2:40])=[N:36]4)[C:25]2=[CH:24][C:23]=1[C:51]#[C:52][C:53]1([CH3:57])[CH2:56][O:55][CH2:54]1)=[CH:33][C:32]([C:41]1[C:42]([F:47])=[N:43][CH:44]=[CH:45][CH:46]=1)=[CH:31][CH:30]=3