Propylenediamine → 5,6-Bis(4-fluorophenyl)-2-methyl-2,3-dihydropyrazine

HRID 336071

反応式

HRID 336071 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)=O)=O)=[CH:4][CH:3]=1.[NH2:19][CH2:20][CH:21]([NH2:23])[CH3:22]>C(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)=[N:23][CH:21]([CH3:22])[CH2:20][N:19]=2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 6567PropylenediamineHCID 1230724,4'-Difluorobenzil

生成物 1

HCID 575436185,6-Bis(4-fluorophenyl)-2-methyl-2,3-dihydropyrazine収率 86%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

First, with ethanol as a solvent, 5.31 g of 4,4′-difluorobenzil (by Tokyo Chemical Industry Co., Ltd.) and 1.60 g of 1,2-diaminopropane (by Tokyo Chemical Industry Co., Ltd.) were mixed, and the mixture was refluxed for three hours. After reaction, a reaction solution was condensed by using an evaporator, and an obtained residue was recrystallized by using ethanol; thus, 2,3-bis(4-fluorophenyl)-5-methyl-5,6-dihydropyrazine was obtained (light yellow powder, yield: 86%).

後処理

  1. temperaturethe mixture was refluxed for three hours
  2. customAfter reaction
  3. customcondensed
  4. customan evaporator
  5. customan obtained residue was recrystallized

出典と根拠

ORDレコード
ord-3e3f3068b37a445a93ca72c14d52bfcf
出典データセット
uspto-grants-2014_11
特許番号
US08889266B2

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