Water → 8-Azido-5-(quinolin-3-yl)-6,7,8,9-tetrahydropyrimido[5,4-b]indolizin-4-amine

HRID 336141ノート

反応式

HRID 336141 の反応式
[N-:1]=[N+:2]=[N-:3].[Na+].CS(O[CH:10]1[CH2:18][CH2:17][C:16]2[N:12]([C:13]3[N:32]=[CH:31][N:30]=[C:29]([NH2:33])[C:14]=3[C:15]=2[C:19]2[CH:20]=[N:21][C:22]3[C:27]([CH:28]=2)=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:11]1)(=O)=O.O>CN(C=O)C>[N:1]([CH:10]1[CH2:18][CH2:17][C:16]2[N:12]([C:13]3[N:32]=[CH:31][N:30]=[C:29]([NH2:33])[C:14]=3[C:15]=2[C:19]2[CH:20]=[N:21][C:22]3[C:27]([CH:28]=2)=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:11]1)=[N+:2]=[N-:3]

参加物

5

反応物 3

HCID 962WaterHCID 33557Sodium AzideHCID 867112814-Amino-5-(quinolin-3-yl)-6,7,8,9-tetrahydropyrimido[5,4-b]indolizin-8-yl methanesulfonate

生成物 1

HCID 867112828-Azido-5-(quinolin-3-yl)-6,7,8,9-tetrahydropyrimido[5,4-b]indolizin-4-amine収率 77%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
80 °C

実験手順

Sodium azide (361 mg) was added to a solution of 4-amino-5-(quinolin-3-yl)-6,7,8,9-tetrahydropyrimido[5,4-b]indolizin-8-yl methanesulfonate (758 mg) obtained in Step 9 in DMF (9 ml) at room temperature, and the mixture was stirred at 80° C. for 4 hours. After cooling, the reaction mixture was poured into water, followed by extraction with ethyl acetate. The organic layer was washed with water and a saturated sodium chloride solution, and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound as a yellow solid (508 mg).

後処理

  1. temperatureAfter cooling
  2. extractionfollowed by extraction with ethyl acetate
  3. washThe organic layer was washed with water
  4. dry with materiala saturated sodium chloride solution, and dried over anhydrous sodium sulfate
  5. distillationThe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-21f0adb07a4a460ea9c3f56ae98b71de
出典データセット
uspto-grants-2014_11
特許番号
US08889666B2

反応ノート

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