Piperazine → 1-(4-Methoxypyridin-2-yl)piperazine

HRID 336360

反応式

HRID 336360 の反応式
Cl[C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][N:3]=1.[NH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>CN1CCCC1=O.O>[CH3:9][O:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:7]=1

参加物

5

反応物 2

HCID 4837PiperazineHCID 19911282-Chloro-4-methoxypyridine

生成物 1

HCID 226481321-(4-Methoxypyridin-2-yl)piperazine収率 16.2%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

46 mg 2-chloro-4-methoxy-pyridine and 277 mg piperazine in 2 mL n-methyl-2-pyrrolidinone were stirred 45 min at 140° C. and 30 min at 200° C. under microwave conditions. The reaction was diluted with water and purified by HPLC to give 10 mg desired product.

後処理

  1. custompurified by HPLC

出典と根拠

ORDレコード
ord-63fe068426d742b984b82fa0b5cd9a08
出典データセット
uspto-grants-2014_11
特許番号
US08889677B2

関連ノート

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