Diisopropylethylamine → HCID 86690175、化合物

HRID 336386ノート

反応式

HRID 336386 の反応式
[CH3:1][NH:2][CH2:3][CH:4]1[CH2:8][CH2:7][O:6][CH2:5]1.[F:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:20]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=3)[N:18]([CH2:28][C:29]([N:31]3[CH2:36][CH2:35][N:34]([C:37]4[CH:42]=[C:41](Cl)[N:40]=[CH:39][N:38]=4)[CH2:33][CH2:32]3)=[O:30])[N:17]=2)=[CH:12][CH:11]=1.CCN(C(C)C)C(C)C>CS(C)=O>[F:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:20]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=3)[N:18]([CH2:28][C:29]([N:31]3[CH2:36][CH2:35][N:34]([C:37]4[CH:42]=[C:41]([N:2]([CH3:1])[CH2:3][CH:4]5[CH2:8][CH2:7][O:6][CH2:5]5)[N:40]=[CH:39][N:38]=4)[CH2:33][CH2:32]3)=[O:30])[N:17]=2)=[CH:12][CH:11]=1

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 16228714Methyl[(oxolan-3-yl)methyl]amineHCID 866901732-(3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(6-chloro-pyrimidin-4-yl)-piperazin-1-yl)-ethanone

生成物 1

HCID 86690175HCID 86690175、化合物収率 75.9%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
80 °C

実験手順

58 mg methyl-(tetrahydro-furan-3-ylmethyl)-amine was added to 50 mg 2-(3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(6-chloro-pyrimidin-4-yl)-piperazin-1-yl)-ethanone and 35 μl DIPEA in 1 mL DMSO. The reaction was stirred 3 h at 80° C. The mixture was purified by HPLC to give 44 mg of the desired product. Rt: 2.13 min (method M), (M+H)+: 575

後処理

  1. customThe mixture was purified by HPLC

出典と根拠

ORDレコード
ord-ffbe3ef9979a4bb79d316677dda8c8f2
出典データセット
uspto-grants-2014_11
特許番号
US08889677B2

反応ノート

読み込み中…