4-nitro-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole → 1-(Tetrahydro-2H-pyran-4-YL)-1H-pyrazol-4-amine
反応式
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([CH:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[CH:8]=1)([O-])=O>CO.[Pd]>[O:12]1[CH2:11][CH2:10][CH:9]([N:7]2[CH:8]=[C:4]([NH2:1])[CH:5]=[N:6]2)[CH2:14][CH2:13]1参加物
4
実験手順
A solution of 4-nitro-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole (568 mg, 2.88 mmol, 1 equiv) in methanol was circulated through a H-Cube® Continuous-flow hydrogenation reactor (ThalesNano) fitted with a palladium on carbon catalyst cartridge at 50° C. The collected solution was concentrated in vacuo to afford product, which was used without further purification (458 mg, 95% yield). LCMS (ESI) m/z: 168.0.
後処理
- concentrationThe collected solution was concentrated in vacuo
- customto afford product, which
- customwas used without further purification (458 mg, 95% yield)
出典と根拠
- ORDレコード
- ord-eb99796e7162433390340b2e346654e3
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08889673B2
反応ノート
読み込み中…