Hydrochloric Acid → HCID 178500867、化合物
反応式
[CH3:1][O:2][C:3](=[O:7])[CH2:4][C:5]#[N:6].[OH:8][NH2:9].Cl>C1COCC1>[CH3:1][O:2][C:3](=[O:7])[CH2:4][C:5](=[NH:6])[NH:9][OH:8]参加物
5
反応条件
- 温度
- 80 °C
実験手順
2-Cyano-acetic acid methyl ester (990 mg, 10 mmol) was dissolved in THF (30 mL). Hydroxy amine (690 mg, HCl salt, 10 mmol) was added thereto, and the mixture was stirred for 2 h at 80° C. After completion of the reaction, 1N HCl was added. The reaction mixture was extracted with EtOAc, and dried over MgSO4. The solvent was removed under reduced pressure, and the residue was used in the next reaction without further purification.
後処理
- additionwas added
- extractionThe reaction mixture was extracted with EtOAc
- dry with materialdried over MgSO4
- customThe solvent was removed under reduced pressure
- customthe residue was used in the next reaction without further purification
出典と根拠
- ORDレコード
- ord-d68248d3b4004215abc9285c5d8be2fb
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08889691B2
反応ノート
読み込み中…