Methanol → 3-Bromotricyclo[3.3.1.13,7]decane-1-methanol

HRID 336582

反応式

HRID 336582 の反応式
O1CCCC1.B.CO.[Br:9][C:10]12[CH2:19][CH:14]3[CH2:15][CH:16]([CH2:18][C:12]([C:20](O)=[O:21])([CH2:13]3)[CH2:11]1)[CH2:17]2>O1CCCC1>[Br:9][C:10]12[CH2:19][CH:14]3[CH2:15][CH:16]([CH2:18][C:12]([CH2:20][OH:21])([CH2:13]3)[CH2:11]1)[CH2:17]2

参加物

5

反応物 3

HCID 887MethanolHCID 308183-Bromoadamantane-1-carboxylic acidHCID 2723981Borane;tetrahydrofuran

生成物 1

HCID 28029653-Bromotricyclo[3.3.1.13,7]decane-1-methanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

In a 250 ml round-bottomed flask, 3-bromoadamantane-1-carboxylic acid (7.89 g) was dissolved in tetrahydrofuran (30 mL). Borane tetrahydrofuran complex (1M in hexane, 60 mL) was added slowly. The mixture was stirred at room temperature overnight. Methanol (20 mL) was added to the solution slowly. After removal of the solvents, methanol (5 mL) was added to the oily residue. Removal of the solvent provided the title compound.

後処理

  1. customAfter removal of the solvents, methanol (5 mL)
  2. additionwas added to the oily residue
  3. customRemoval of the solvent

出典と根拠

ORDレコード
ord-2fef7fb5ad81442a8b70465b243a5d5d
出典データセット
uspto-grants-2014_11
特許番号
US08889675B2

関連ノート

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