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Acetic acid, 2-(4-formylphenoxy)- → 2-(4-(5,7-Dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic acid, 2-(4-formylphenoxy)- | HCID 89177 | — |
| 反応物 | 2-Amino-4,6-dimethoxybenzamide | HCID 20349016 | — |
| 反応物 | 2-(4-hydroxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one | HCID 136038000 | — |
| 生成物 | 2-(4-(5,7-Dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetic acid | HCID 136038018 | 21% |
反応手順
2-(4-(5,7-Dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetic acid was synthesized from 2-amino-4,6-dimethoxy-benzamide and (4-formyl phenoxy)acetic acid, using the method described for 2-(4-hydroxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one. 2-(4-(5,7-Dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetic acid (135 mg, 21%) was isolated as an off-white solid. Selected data: MS (m/z): 357.04; MP 287-290° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08889698B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-03dd7199c00e40c0a0cce95de127152e |
| 出典メモ | uspto-grants-2014_11 |