p-Toluenesulfonic acid → 5,7-dimethoxy-2-(4-(morpholinomethyl)phenyl)quinazolin-4(3H)-one

HRID 336721

反応式

HRID 336721 の反応式
[NH2:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[C:7]([O:13][CH3:14])[C:3]=1[C:4]([NH2:6])=[O:5].[N:15]1([CH2:21][C:22]2[CH:29]=[CH:28][C:25]([CH:26]=O)=[CH:24][CH:23]=2)[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1.OS([O-])=O.[Na+].CC1C=CC(S(O)(=O)=O)=CC=1.C([O-])(O)=O.[Na+]>CN(C)C(=O)C.O>[CH3:14][O:13][C:7]1[CH:8]=[C:9]([O:11][CH3:12])[CH:10]=[C:2]2[C:3]=1[C:4](=[O:5])[NH:6][C:26]([C:25]1[CH:24]=[CH:23][C:22]([CH2:21][N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)=[CH:29][CH:28]=1)=[N:1]2

参加物

8

反応物 5

HCID 6101p-Toluenesulfonic acidHCID 516892Sodium BicarbonateHCID 27954984-[(Morpholin-4-yl)methyl]benzaldehydeHCID 203490162-Amino-4,6-dimethoxybenzamideHCID 23665763Sodium Bisulfite

生成物 1

HCID 1360380055,7-dimethoxy-2-(4-(morpholinomethyl)phenyl)quinazolin-4(3H)-one

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 31374Dimethylacetamide溶媒

反応条件

温度
150 °C

実験手順

To a solution of 2-amino-4,6-dimethoxy-benzamide (150 mg, 0.76 mmol) and 4-morpholin-4-ylmethyl benzaldehyde (156 mg, 0.76 mmol) in N,N-dimethyl acetamide (10 mL), NaHSO3 (150 mg, 0.84 mmol) and p-TSA (174 mg, 0.91 mmol) were added and the reaction mixture was heated at 150° C. for 5 h. The reaction mixture was cooled to room temperature, water was added and the mixture was neutralized with NaHCO3. The solvent was removed under reduced pressure to give the crude product, which was purified by column chromatography to give 5,7-dimethoxy-2-(4-(morpholinomethyl)phenyl)quinazolin-4(3H)-one, which was converted to the hydrochloride salt (165 mg, 51%). Selected data: MS (ES) m/z: 382.07; MP 206-208° C. (at decomposition).

後処理

  1. temperatureThe reaction mixture was cooled to room temperature
  2. customThe solvent was removed under reduced pressure
  3. customto give the crude product, which
  4. customwas purified by column chromatography

出典と根拠

ORDレコード
ord-6e0a664d942f43c194a3ce9759ed41eb
出典データセット
uspto-grants-2014_11
特許番号
US08889698B2

関連ノート

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