関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 2(3H)-Benzofuranone, 3,3-dimethyl- | HCID 595620 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-Hydroxy-alpha,alpha-dimethyl-benzeneacetamide | HCID 86663248 | — |
反応手順
3,3-Dimethylbenzofuran-2(3H)-one (Example 198a, 19.7 g) was dissolved in 7N ammonia in methanol (50 mL) under nitrogen. The resulting solution was stirred at 25° C. for 16 h. The reaction mixture was evaporated to afford crude product. The solid was triturated with diethyl ether and filtered to give the subtitle compound (15.34 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08889692B2 |
|---|
| 出典データセット | uspto-grants-2014_11 |
|---|
| ORD ID | ord-8158e9f3f7074379993b11da7f2de2d8 |
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| 出典メモ | uspto-grants-2014_11 |
|---|
