Hydrochloric Acid → (RS)-2-bromo-6-(1-hydroxyheptyl)anisole

HRID 337191

反応式

HRID 337191 の反応式
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[C:3]=1[O:9][CH3:10].[CH:11](=[O:18])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].Cl>C1COCC1>[Br:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH:11]([OH:18])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[C:3]=1[O:9][CH3:10]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 8130HeptanalHCID 181584Benzene, 1,3-dibromo-2-methoxy-

生成物 1

HCID 59544889(RS)-2-bromo-6-(1-hydroxyheptyl)anisole収率 79%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
40 °C

実験手順

To a THF solution of 2,6-dibromoanisole (10 g, 37.6 mmol) was added Mg (0.90 g, 37.6 mmol), and the mixture was heated and stirred at 40° C. Under ice-cooling, n-heptanal (47.2 g, 41.3 mmol) was added dropwise. Aqueous hydrochloric acid solution was added to the reaction mixture, this was extracted with ethyl acetate, and the solvent was distilled off to obtain 8.95 g of a compound (1).

後処理

  1. temperaturethe mixture was heated
  2. temperatureUnder ice-cooling
  3. extractionthis was extracted with ethyl acetate
  4. distillationthe solvent was distilled off

出典と根拠

ORDレコード
ord-53e03c4968f94623a0aa01cae23e16bf
出典データセット
uspto-grants-2014_11
特許番号
US08889722B2

関連ノート

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