Hydrochloric Acid → (RS)-2-bromo-6-(1-hydroxyheptyl)anisole
反応式
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[C:3]=1[O:9][CH3:10].[CH:11](=[O:18])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].Cl>C1COCC1>[Br:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH:11]([OH:18])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[C:3]=1[O:9][CH3:10]参加物
5
反応条件
- 温度
- 40 °C
実験手順
To a THF solution of 2,6-dibromoanisole (10 g, 37.6 mmol) was added Mg (0.90 g, 37.6 mmol), and the mixture was heated and stirred at 40° C. Under ice-cooling, n-heptanal (47.2 g, 41.3 mmol) was added dropwise. Aqueous hydrochloric acid solution was added to the reaction mixture, this was extracted with ethyl acetate, and the solvent was distilled off to obtain 8.95 g of a compound (1).
後処理
- temperaturethe mixture was heated
- temperatureUnder ice-cooling
- extractionthis was extracted with ethyl acetate
- distillationthe solvent was distilled off
出典と根拠
- ORDレコード
- ord-53e03c4968f94623a0aa01cae23e16bf
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08889722B2
反応ノート
読み込み中…