反応式
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][NH2:11].[CH3:12][CH:13]([C:17](=O)[CH3:18])[C:14](=O)[CH3:15].O.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[C:17]([CH3:18])=[C:13]([CH3:12])[C:14]([CH3:15])=[N:11]1参加物
6
実験手順
200 mg of 2-methoxyphenyl hydrazine hydrochloride was dissolved in 4 ml of ethanol, and 134 μl of 3-methyl-2,4-pentanedione was added and heated at reflux for 3 hours. To the reaction mixture was added 50 ml of water, neutralized with a saturated aqueous solution of sodium carbonate, and extracted with 60 ml of ethyl acetate. After the organic layer was dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure to yield 209.8 mg of the title compound.
後処理
- temperatureheated
- temperatureat reflux for 3 hours
- extractionextracted with 60 ml of ethyl acetate
- dry with materialAfter the organic layer was dried over anhydrous magnesium sulfate
- distillationthe solvent was distilled off under reduced pressure
出典と根拠
- ORDレコード
- ord-6c70bd91c2274e9ba033fb8f22b7f8e0
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08889727B2
関連ノート
読み込み中…