1-(2-Benzyloxyphenyl)-4-fluoro-3,5-dimethyl-1H-pyrazole → 2-(4-Fluoro-3,5-dimethyl-1H-pyrazol-1-yl)phenol
反応式
C([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]1[C:19]([CH3:20])=[C:18]([F:21])[C:17]([CH3:22])=[N:16]1)C1C=CC=CC=1>CO.[Pd]>[F:21][C:18]1[C:17]([CH3:22])=[N:16][N:15]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[OH:8])[C:19]=1[CH3:20]参加物
4
実験手順
416 mg of 1-(2-benzyloxyphenyl)-4-fluoro-3,5-dimethyl-1H-pyrazol was dissolved in 16 ml of methanol, and 42.6 mg of 10% palladium/carbon was added and stirred under hydrogen atmosphere at room temperature for a whole day and night. After the insoluble matter was filtered off, the filtrate was distilled off under reduced pressure and the resulting residue was purified using silica gel column chromatography (hexane:ethyl acetate=5:1) to yield 290 mg of the title compound.
後処理
- filtrationAfter the insoluble matter was filtered off
- distillationthe filtrate was distilled off under reduced pressure
- customthe resulting residue was purified
出典と根拠
- ORDレコード
- ord-7cf7066bbafc45cbbdaccda731848d36
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08889727B2
反応ノート
読み込み中…