3-Hydroxy-4-nitrophenyl acetate → 4-Amino-3-hydroxyphenyl acetate

HRID 337359

反応式

HRID 337359 の反応式
[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[C:7]([OH:14])[CH:6]=1)(=[O:3])[CH3:2]>C(OCC)(=O)C.[Pd]>[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[C:7]([OH:14])[CH:6]=1)(=[O:3])[CH3:2]

参加物

4

反応物 1

HCID 201396903-Hydroxy-4-nitrophenyl acetate

生成物 1

HCID 197705154-Amino-3-hydroxyphenyl acetate収率 97.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 3-hydroxy-4-nitrophenyl acetate (3.0 g) in ethyl acetate (50 mL), 300 mg of palladium/carbon (10%) was added under nitrogen atmosphere. The resulting mixture was stirred under hydrogen atmosphere for 10 h at room temperature. The insoluble material was filtered off and the filtrate was concentrated under reduced pressure. The residue was purified by the column chromatography over silica gel using hexane/ethyl acetate(1:1) to give the title compound (2.48 g).

後処理

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe residue was purified by the column chromatography over silica gel

出典と根拠

ORDレコード
ord-5b6dd432e2124df6b9238f3de8079bad
出典データセット
uspto-grants-2014_11
特許番号
US08889727B2

関連ノート

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