Nitric Acid → 1,4-Dimethoxy-2-methyl-5-nitrobenzene

HRID 337363

反応式

HRID 337363 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[CH3:11].[N+:12]([O-])([OH:14])=[O:13]>C(O)(=O)C.O>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N+:12]([O-:14])=[O:13])[C:6]([O:9][CH3:10])=[CH:5][C:4]=1[CH3:11]

参加物

5

反応物 2

HCID 944Nitric AcidHCID 905522,5-Dimethoxytoluene

生成物 1

HCID 27780951,4-Dimethoxy-2-methyl-5-nitrobenzene収率 96.5%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒2 回HCID 962Water溶媒

反応条件

温度
40 °C

実験手順

2,5-dimethoxy toluene (6.0 g) was dissolved in acetic acid (20 mL). To the solution, a solution of fuming nitric acid (d=1.50, 4.32 g) in acetic acid (10 mL) was added dropwise at 40° C. over a period of 5 min. The mixture was stirred at 40° C. for 30 min. The reaction mixture was then allowed to cool to room temperature, which was stirred for another 30 min. Then the reaction mixture was diluted with cold water (300 mL). The resulting precipitate was filtered washed with cold water (100 mL) and dried under reduced pressure to afford the title compound (7.5 g).

後処理

  1. temperatureto cool to room temperature
  2. stirringwhich was stirred for another 30 min
  3. filtrationThe resulting precipitate was filtered
  4. washwashed with cold water (100 mL)
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-deeb7964a5b44e7e8abe2dea31a57b0e
出典データセット
uspto-grants-2014_11
特許番号
US08889727B2

関連ノート

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