Benzoyl Peroxide → 2-(Bromomethyl)-1-chloro-4-(2-methoxyethoxy)benzene

HRID 337619ノート

反応式

HRID 337619 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][O:11][CH3:12])=[CH:4][C:3]=1[CH3:13].C1C(=O)N([Br:21])C(=O)C1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:21][CH2:13][C:3]1[CH:4]=[C:5]([O:8][CH2:9][CH2:10][O:11][CH3:12])[CH:6]=[CH:7][C:2]=1[Cl:1]

参加物

5

反応物 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 22467254HCID 22467254、化合物

生成物 1

HCID 591775552-(Bromomethyl)-1-chloro-4-(2-methoxyethoxy)benzene

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

A mixture of 1-chloro-4-(2-methoxyethoxy)-2-methylbenzene (1 eq.) from the previous step, NBS (1.1 eq.) and benzoyl peroxide (0.05 eq.) in CCl4 (0.2 M) was refluxed for 2 h. The volatiles were then removed in vacuo and the resulting residue was suspended in hexanes. The insolubles were removed via filtration and washed further with hexanes. The filtrate was concentrated in vacuo to afford the title compound as a colorless oil.

後処理

  1. temperaturewas refluxed for 2 h
  2. customThe volatiles were then removed in vacuo
  3. customThe insolubles were removed via filtration
  4. washwashed further with hexanes
  5. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-34047ed8e1f54db7a6d2fbe6d7aa3373
出典データセット
uspto-grants-2014_11
特許番号
US08889714B2

反応ノート

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