Trifluoroacetic acid → HCID 89963070、化合物
反応式
C(OC(=O)[N:7]([S:13]([C:16]1[CH:21]=[C:20]([Cl:22])[C:19]([O:23][C@H:24]2[CH2:28][CH2:27][CH2:26][C@@H:25]2[C:29]2[N:33]([CH3:34])[N:32]=[CH:31][CH:30]=2)=[CH:18][C:17]=1[F:35])(=[O:15])=[O:14])[C:8]1[N:9]=[CH:10][S:11][CH:12]=1)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[Cl:22][C:20]1[C:19]([O:23][C@H:24]2[CH2:28][CH2:27][CH2:26][C@@H:25]2[C:29]2[N:33]([CH3:34])[N:32]=[CH:31][CH:30]=2)=[CH:18][C:17]([F:35])=[C:16]([S:13]([NH:7][C:8]2[N:9]=[CH:10][S:11][CH:12]=2)(=[O:15])=[O:14])[CH:21]=1参加物
4
実験手順
The reaction and aftertreatment were conducted in the same manner as in Example 1b by using the tert-butyl[(5-chloro-2-fluoro-4-{[(1S*,2R*)-2-(1-methyl-1H-pyrazol-5-yl)cyclopentyl]oxy}phenyl)sulfonyl](1,3-thiazol-4-yl)carbamate (520 mg, 0.934 mmol) prepared in Example 11a, trifluoroacetic acid (5.0 mL) and dichloromethane (5.0 mL), to yield the title compound (427 mg, 99%) as a colorless solid.