Ethylene Glycol → 8,8-Difluoro-6-iodo-1,4-dioxaspiro[4.5]dec-6-ene
反応式
[F:1][C:2]1([F:10])[CH2:7][CH2:6][C:5](=[O:8])[C:4]([I:9])=[CH:3]1.[CH2:11](O)[CH2:12][OH:13].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1C=CC=CC=1>[F:1][C:2]1([F:10])[CH2:7][CH2:6][C:5]2([O:13][CH2:12][CH2:11][O:8]2)[C:4]([I:9])=[CH:3]1参加物
5
実験手順
The reaction and aftertreatment were conducted in the same manner as in Example 67a by using the 4,4-difluoro-2-iodocyclohex-2-en-1-one (1.46 g, 5.66 mmol) prepared in Example 88c, ethylene glycol (750 mg, 12.1 mmol), p-toluenesulfonic acid hydrate (60 mg, 0.31 mmol) and benzene (30 mL), to yield a mixture of the title compound and a by-product.
後処理
- customThe reaction and aftertreatment
- customto yield
出典と根拠
- ORDレコード
- ord-ba2b597e077a47bdb3f4cfb45b79031e
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08889741B2
反応ノート
読み込み中…