Sodium Hydroxide → 5-[4-(1-acetylazetidin-2-yl)phenyl]-6-chloro-1H-indole-3-carboxylic acid

HRID 338335ノート

反応式

HRID 338335 の反応式
[C:1]([N:4]1[CH2:7][CH2:6][CH:5]1[C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:15]=[C:16]3[C:20](=[CH:21][C:22]=2[Cl:23])[NH:19][CH:18]=[C:17]3[C:24]([O:26]C)=[O:25])=[CH:10][CH:9]=1)(=[O:3])[CH3:2].[OH-].[Na+]>CO>[C:1]([N:4]1[CH2:7][CH2:6][CH:5]1[C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:15]=[C:16]3[C:20](=[CH:21][C:22]=2[Cl:23])[NH:19][CH:18]=[C:17]3[C:24]([OH:26])=[O:25])=[CH:10][CH:9]=1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 86698680methyl 5-[4-(1-acetylazetidin-2-yl)phenyl]-6-chloro-1H-indole-3-carboxylate

生成物 1

HCID 866986815-[4-(1-acetylazetidin-2-yl)phenyl]-6-chloro-1H-indole-3-carboxylic acid収率 7.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
70 °C

実験手順

To a solution of methyl 5-[4-(1-acetylazetidin-2-yl)phenyl]-6-chloro-1H-indole-3-carboxylate (40 mg, 0.11 mmol) in methanol (8 mL) was added 1.0M aq. NaOH (2.0 mL, 2.0 mmol). The mixture was stirred at 70° C. for 24 hours. The mixture was adjusted to pH 7 and purified by reverse phase HPLC to give the title compound (3 mg, 7% yield) as a white solid.

後処理

  1. custompurified by reverse phase HPLC

出典と根拠

ORDレコード
ord-7989a53bf3474d7ca803e2a26ca1a1c7
出典データセット
uspto-grants-2014_11
特許番号
US08889730B2

反応ノート

読み込み中…