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4-Aminobenzoic Acid → HCID 67078597、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Aminobenzoic Acid | HCID 978 | — |
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 反応物 | 3,4,5-Trimethoxybenzylamine | HCID 87736 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | HCID 67078597 | HCID 67078597 | 94.6% |
反応手順
N,N-carbonyldiimidazole (1.62 g, 10 mmol), 3,4,5-trimethoxybenzyl amine (1.97 g, 10 mmol), p-aminobenzoic acid (1.52 g, 10 mmol), and 10 ml of 1 mol/L sodium hydroxide are used according to the method for the production of compound III in Method two to obtain 3.54 g of 4-[(3,4,5-trimethoxybenzylureido)methyl]benzoic acid (intermediate M-35) as a white solid, with a yield of 94.6%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08889876B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-3d01f9b77e7e44969a51c2bde6985c6f |
| 出典メモ | uspto-grants-2014_11 |