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4-Aminobenzoic Acid → 4-[3-(2-Naphthylmethyl)ureidomethyl]benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Aminobenzoic Acid | HCID 978 | — |
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 反応物 | 1-(2-Naphthyl)methanamine | HCID 137282 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | 4-[3-(2-Naphthylmethyl)ureidomethyl]benzoic acid | HCID 67078818 | 93.3% |
反応手順
N,N-carbonyldiimidazole (1.62 g, 10 mmol), 2-aminomethylnaphthalene (1.57 g, 10 mmol), p-aminobenzoic acid (1.52 g, 10 mmol), and 10 ml of 1 mol/L sodium hydroxide solution are used according to the method for the production of compound III in Method two to obtain 3.12 g of 4-[3-(2-naphthylmethyl)ureidomethyl]benzoic acid (intermediate M-40) as a white solid, with a yield of 93.3%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08889876B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-d27127dc63264f79b72c504e3643f8ce |
| 出典メモ | uspto-grants-2014_11 |