反应详情

N,N-carbonyldiimidazole (1.62 g, 10 mmol), 2-aminomethylnaphthalene (1.57 g, 10 mmol), p-aminobenzoic acid (1.52 g, 10 mmol), and 10 ml of 1 mol/L sodium hydroxide solution are used according to the method for the production of compound III in Method two to obtain 3.12 g of 4-[3-(2-naphthylmethyl)ureidomethyl]benzoic acid (intermediate M-40) as a white solid, with a yield of 93.3%.