3-Bromo-4-hydroxybenzaldehyde → HCID 136183493、化合物

HRID 338786

反応式

HRID 338786 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[OH:10])[CH:5]=O.[NH2:11][C:12]1[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[CH:14][C:13]=1[SH:22]>CN(C)C=O>[Br:1][C:2]1[CH:3]=[C:4]([C:5]2[S:22][C:13]3[CH:14]=[CH:15][C:16]([C:18]([F:19])([F:20])[F:21])=[CH:17][C:12]=3[N:11]=2)[CH:7]=[CH:8][C:9]=1[OH:10]

参加物

4

反応物 2

HCID 763083-Bromo-4-hydroxybenzaldehydeHCID 880422-Amino-4-(trifluoromethyl)benzenethiol

生成物 1

HCID 136183493HCID 136183493、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

In a N,N-dimethylformamide (DMF) solvent, a suspension of 3-bromo-4-hydroxybenzaldehyde (1.0 eq.) and 2-amino-4-(trifluoromethyl)benzenethiol (1.0 eq.) was heated at a temperature of 100° C. After cooling, DMF was removed therefrom under reduced pressure. Methylene chloride was added to the resultant solid, and the produced precipitate was filtered, and washed with methylene chloride to obtain a solid target product.

後処理

  1. temperatureAfter cooling
  2. customDMF was removed
  3. additionMethylene chloride was added to the resultant solid
  4. filtrationthe produced precipitate was filtered
  5. washwashed with methylene chloride
  6. customto obtain a solid target product

出典と根拠

ORDレコード
ord-a60606d2f7fa4625a89673b064524efe
出典データセット
uspto-grants-2014_11
特許番号
US08889881B2

関連ノート

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