Sodium Hydroxide → Ethyl 2-(4-formylphenoxy)-2-methylpropanoic acid

反応式

[CH:1]([C:3]1[CH:17]=[CH:16][C:6]([O:7][C:8]([CH3:15])([CH3:14])[C:9]([O:11]CC)=[O:10])=[CH:5][CH:4]=1)=[O:2].[OH-].[Na+].O1CCO[CH2:22][CH2:21]1>>[CH2:21]([CH2:15][C:8]([O:7][C:6]1[CH:5]=[CH:4][C:3]([CH:1]=[O:2])=[CH:17][CH:16]=1)([CH3:14])[C:9]([OH:11])=[O:10])[CH3:22]

参加物

反応物 3

HCID 14798Sodium Hydroxide

HCID 312751,4-Dioxane

HCID 13134808Ethyl 2-(4-formylphenoxy)-2-methylpropanoate

生成物 1

HCID 86709921Ethyl 2-(4-formylphenoxy)-2-methylpropanoic acid収率 99%

実験手順

The obtained Compound 97a (1.0 eq.) was dissolved in 1,4-dioxane, and 1 N NaOH (1.4 eq.) was added thereto. The reaction mixture was stirred at room temperature, and after a volatile material was evaporated, the residual was distributed between methylene chloride and water. An water layer was acidified by using a 12 N HCl and extracted by using methylene chloride. An organic layer was evaporated to obtain Compound 97c.