Hydrazine → Methyl 6-hydrazinylpyridine-3-carboxylate

HRID 338847ノート

反応式

HRID 338847 の反応式
F[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1.[NH2:12][NH2:13]>C1COCC1>[NH:12]([C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1)[NH2:13]

参加物

4

反応物 2

HCID 9321HydrazineHCID 13758765Methyl 6-fluoropyridine-3-carboxylate

生成物 1

HCID 55280209Methyl 6-hydrazinylpyridine-3-carboxylate収率 89.5%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of methyl 6-fluoronicotinate (13.9 g, 89.60 mmol) and hydrazine (5.625 ml, 179.2 mmol) in THF (200 mL) were heated at 56° C. for 2 hours. After cooling to ambient temperature, the solvent was removed under reduced pressure and water (200 mL) was added. The suspension was stirred at ambient temperature for 1 hour. The solid was collected by filtration, washed with water and dried to give methyl 6-hydrazinylnicotinate (13.4 g, 89.5%) as a solid.

後処理

  1. customthe solvent was removed under reduced pressure and water (200 mL)
  2. additionwas added
  3. filtrationThe solid was collected by filtration
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-c937c3d86bc743d4970c90d94f93d68f
出典データセット
uspto-grants-2014_11
特許番号
US08889704B2

反応ノート

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