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llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
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Hydrochloric Acid → (S)-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-8-((R)-1-methoxypropan-2-yloxy)quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-amine dihydrochloride

HRID 338985
ノート
印刷プレビュー

反応式

HRID 338985 の反応式
[F:1][C:2]([F:44])([F:43])[C@H:3]([N:30]1[CH2:34][CH2:33][C@H:32]([NH:35]C(=O)OC(C)(C)C)[CH2:31]1)[C:4]1[CH:5]=[CH:6][C:7]2[N:8]([C:10]([C:13]3[CH:22]=[CH:21][C:20]4[C:15](=[C:16]([O:24][C@H:25]([CH3:29])[CH2:26][O:27][CH3:28])[CH:17]=[C:18]([F:23])[CH:19]=4)[N:14]=3)=[N:11][N:12]=2)[CH:9]=1.[ClH:45]>ClCCl.C(#N)C>[ClH:45].[ClH:45].[F:44][C:2]([F:1])([F:43])[C@H:3]([N:30]1[CH2:34][CH2:33][C@H:32]([NH2:35])[CH2:31]1)[C:4]1[CH:5]=[CH:6][C:7]2[N:8]([C:10]([C:13]3[CH:22]=[CH:21][C:20]4[C:15](=[C:16]([O:24][C@H:25]([CH3:29])[CH2:26][O:27][CH3:28])[CH:17]=[C:18]([F:23])[CH:19]=4)[N:14]=3)=[N:11][N:12]=2)[CH:9]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 86707494tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-8-((R)-1-methoxypropan-2-yloxy)quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-ylcarbamate

生成物 1

HCID 86707495(S)-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-8-((R)-1-methoxypropan-2-yloxy)quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-amine dihydrochloride収率 792%

試薬・触媒・溶媒 2

HCID 6342
Acetonitrile
溶媒
HCID 6344Dichloromethane溶媒

実験手順

To a solution of tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-8-((R)-1-methoxypropan-2-yloxy)quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-ylcarbamate (0.12 g, 0.19 mmol) in dichloromethane (0.5 mL) was added hydrochloric acid (5-6M in 2-propanol; 9.5 mL, 0.61 mmol). The reaction mixture was stirred at ambient temperature for 30 minutes. The solvent was removed under reduced pressure, and the solid obtained was suspended in acetonitrile (3 mL) and stirred at ambient temperature for 5 minutes. The solid formed was collected by vacuum filtration to give the title compound (0.89 g, 79%). LCMS APCI (+) m/z 519 (M+H). Specific rotation: [α]24D=2.44° (c=0.97, MeOH).

後処理

  1. customThe solvent was removed under reduced pressure
  2. customthe solid obtained
  3. stirringstirred at ambient temperature for 5 minutes
  4. customThe solid formed
  5. filtrationwas collected by vacuum filtration

出典と根拠

ORDレコード
ord-94b90d02ceae4ee1acc51e71eb339d0b
出典データセット
uspto-grants-2014_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08889704B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート