Methane → 2-(Methoxymethyl)aniline

HRID 339005ノート

反応式

HRID 339005 の反応式
[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N+:10]([O-])=O.[H][H].C>CO.O=[Pt]=O>[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH2:10]

参加物

6

反応物 3

HCID 297MethaneHCID 126166891-(Methoxymethyl)-2-nitrobenzeneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 123343062-(Methoxymethyl)aniline収率 97%

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 887Methanol溶媒

実験手順

A solution of 1-(methoxymethyl)-2-nitrobenzene (4.30 g, 25.7 mmol) and PtO2 (0.29 g, 1.29 mmol) in MeOH (30 mL) was charged with 1 atmosphere hydrogen and stirred at ambient temperature for 1 hour. Charcoal (5 g) was added and the reaction mixture was stirred for 10 minutes. The solid was removed by filtration and washed with methanol. The filtrate was concentrated under reduced pressure to give 2-(methoxymethyl)aniline (3.42 g, 96.9%) as a solid.

後処理

  1. stirringthe reaction mixture was stirred for 10 minutes
  2. customThe solid was removed by filtration
  3. washwashed with methanol
  4. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-f7367e47b3244552ae1321ad6a778546
出典データセット
uspto-grants-2014_11
特許番号
US08889704B2

反応ノート

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