Hydrochloric Acid → 8-(1,3-Dimethoxypropan-2-yloxy)-2-methylquinoline

HRID 339056

反応式

HRID 339056 の反応式
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5]([OH:12])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[CH3:32][O:33][CH2:34][CH:35](O)[CH2:36][O:37][CH3:38].CC(OC(/N=N/C(OC(C)C)=O)=O)C.Cl>C1COCC1.C(OCC)(=O)C.O>[CH3:32][O:33][CH2:34][CH:35]([O:12][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:4]=1[N:3]=[C:2]([CH3:1])[CH:11]=[CH:10]2)[CH2:36][O:37][CH3:38]

参加物

9

反応物 5

HCID 313Hydrochloric AcidHCID 11776TriphenylphosphineHCID 121901,3-Dimethoxy-2-propanolHCID 132242-Methyl-8-hydroxyquinolineHCID 5363146Diisopropyl azodicarboxylate

生成物 1

HCID 709841378-(1,3-Dimethoxypropan-2-yloxy)-2-methylquinoline収率 89.15%

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 2-methylquinolin-8-ol (4.10 g, 25.76 mmol), PPh3 (16.89 g, 64.39 mmol) and 1,3-dimethoxypropan-2-ol (4.02 g, 33.48 mmol) in THF (20 mL) was added DIAD (8.40 mL, 41.21 mmol) dropwise at ambient temperature. The reaction mixture was stirred at room temperature for two days. 4 N HCl (7.73 mL, 30.91 mmol in water), water (20 mL), and ethyl acetate (50 mL) were added. The aqueous layer was separated and washed with ethyl acetate. The aqueous layer was neutralized with ammonium hydroxide to about pH 9 and extracted with ethyl acetate (50 mL). The organic layer was separated, washed with brine, dried (sodium sulfate), filtered and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel (1:2 hexane/ethyl acetate) to give 8-(1,3-dimethoxypropan-2-yloxy)-2-methylquinoline (6.00 g, 89.15%) as an oil.

後処理

  1. customThe aqueous layer was separated
  2. washwashed with ethyl acetate
  3. extractionextracted with ethyl acetate (50 mL)
  4. customThe organic layer was separated
  5. washwashed with brine
  6. dry with materialdried (sodium sulfate)
  7. filtrationfiltered
  8. concentrationconcentrated under reduced pressure
  9. customThe residue was purified by flash chromatography on silica gel (1:2 hexane/ethyl acetate)

出典と根拠

ORDレコード
ord-d2d57cd034be462d8e17eb4ed307e329
出典データセット
uspto-grants-2014_11
特許番号
US08889704B2

関連ノート

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