Ethanol → Ethyl 2-oxo-1-phenylpyrrolidine-3-carboxylate

HRID 339604ノート

反応式

HRID 339604 の反応式
S(Cl)(Cl)=O.[O:5]=[C:6]1[CH:10]([C:11]([OH:13])=[O:12])[CH2:9][CH2:8][N:7]1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[CH2:20](O)[CH3:21]>>[O:5]=[C:6]1[CH:10]([C:11]([O:13][CH2:20][CH3:21])=[O:12])[CH2:9][CH2:8][N:7]1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

4

反応物 3

HCID 702EthanolHCID 24386Thionyl ChlorideHCID 30437622-Oxo-1-phenylpyrrolidine-3-carboxylic acid

生成物 1

HCID 86700963Ethyl 2-oxo-1-phenylpyrrolidine-3-carboxylate収率 79%

反応条件

温度
80 °C

実験手順

Thionyl chloride is added at 0° C. (5.8 g) to a solution of 2-oxo-1-phenylpyrrolidine-3-carboxylic acid (5 g) in ethanol, and the batch is stirred at 80° C. for 4 h. When the reaction is complete, the batch is concentrated in vacuo, the residue is taken up in water and extracted with ethyl acetate. The organic phase is washed with saturated sodium bicarbonate solution and saturated sodium chloride solution and dried over sodium sulfate, giving ethyl 2-oxo-1-phenylpyrrolidine-3-carboxylate (4.5 g, 79%);

後処理

  1. concentrationthe batch is concentrated in vacuo
  2. extractionextracted with ethyl acetate
  3. washThe organic phase is washed with saturated sodium bicarbonate solution and saturated sodium chloride solution
  4. dry with materialdried over sodium sulfate

出典と根拠

ORDレコード
ord-0bb585ce4b9e4890bac05b1936a9b8a1
出典データセット
uspto-grants-2014_11
特許番号
US08895535B2

反応ノート

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