1-Azido-3-(4-methoxy-phenyl)-propan-2-ol → 1-Amino-3-(4-methoxyphenyl)propan-2-ol

HRID 33968ノート

反応式

HRID 33968 の反応式
[N:1]([CH2:4][CH:5]([OH:15])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=1)=[N+]=[N-].[H][H]>CO.[OH-].[OH-].[Pd+2]>[NH2:1][CH2:4][CH:5]([OH:15])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=1

参加物

5

反応物 2

HCID 597965141-Azido-3-(4-methoxy-phenyl)-propan-2-olHCID 178418361HCID 178418361、化合物

生成物 1

HCID 597965051-Amino-3-(4-methoxyphenyl)propan-2-ol

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

To a stirring solution of 1-azido-3-(4-methoxy-phenyl)-propan-2-ol (1.3 g, 6.3 mmol) in 50 mL methanol under a nitrogen atmosphere was added 10 mg of 10% Pd(OH)2/C. The mixture was stirred under a balloon atmosphere of hydrogen for 18 h. The reaction mixture was filtered through a bed of celite, and the filtrate reduced to a clear oil under reduced pressure. M+1=170.

後処理

  1. filtrationThe reaction mixture was filtered through a bed of celite

出典と根拠

ORDレコード
ord-2eba02d979a249f3b4fdd36dca0cf6c2
出典データセット
uspto-grants-2008_09
特許番号
US07429594B2

反応ノート

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