ethyl 2-chloro-1-methyl-5-phenyl-1H-pyrrole-3-carboxylate → Ethyl 5-phenyl-1H-pyrrole-3-carboxylate

HRID 339726ノート

反応式

HRID 339726 の反応式
Cl[C:2]1[N:3](C)[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:5][C:6]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8]>CO.[Pd]>[C:12]1([C:4]2[NH:3][CH:2]=[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH:5]=2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

参加物

4

反応物 1

HCID 11832263ethyl 2-chloro-1-methyl-5-phenyl-1H-pyrrole-3-carboxylate

生成物 1

HCID 10242379Ethyl 5-phenyl-1H-pyrrole-3-carboxylate収率 97%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Ethyl 2-chloro-1-methyl-5-phenyl-1H-pyrrole-3-carboxylate (2.4 g, 9.1 mmol) and 10% Pd/C (100 mg) was dissolved in methanol (50 ml) at room temperature. The reaction mixture was hydrogenated for 6 hrs at room temperature and the resulting solution was filtered. After evaporated under reduced pressure, the residue was purified with normal phase preparative column chromatography to produce title compound (1.9g, 91%) as white solid.

後処理

  1. filtrationthe resulting solution was filtered
  2. customAfter evaporated under reduced pressure
  3. customthe residue was purified with normal phase preparative column chromatography

出典と根拠

ORDレコード
ord-12bd385e253842538f585ceee5c28163
出典データセット
uspto-grants-2014_11
特許番号
US08895558B2

反応ノート

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