Thionyl Chloride → HCID 66888232、化合物
反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[N:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)[CH:4]=[CH:3][CH:2]=1.O=S(Cl)[Cl:26]>CO>[ClH:26].[N:11]1([C:9]2[CH:8]=[CH:7][CH:6]=[C:5]3[C:10]=2[N:1]=[CH:2][CH:3]=[CH:4]3)[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1参加物
4
実験手順
tert-Butyl 4-(quinolin-8-yl)piperazine-1-carboxylate (2.4 g, 7.66 mmol) was dissolved in methanol (50 ml) and SOCl2 was added to the solution dropwise at 0° C. The resulting solution was refluxed for 1 day and evaporated under reduced pressure. EtOAc (50 ml) was added to the residue and stirred for 2 hours to produce light yellow solid. The title compound was collected by filtration (1.7 g, 89%) as light yellow solid.
後処理
- temperatureThe resulting solution was refluxed for 1 day
- customevaporated under reduced pressure
- additionEtOAc (50 ml) was added to the residue
- customto produce light yellow solid
- filtrationThe title compound was collected by filtration (1.7 g, 89%) as light yellow solid
出典と根拠
- ORDレコード
- ord-f1f294979e2845dfb10f4df00e780a8c
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08895558B2
反応ノート
読み込み中…