Thionyl Chloride → HCID 86702828、化合物

HRID 339774ノート

反応式

HRID 339774 の反応式
[N:1]1([CH2:7][C@H:8]([OH:11])[CH2:9][OH:10])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[S:12](Cl)([Cl:14])=[O:13]>C(Cl)Cl>[ClH:14].[O:13]=[S:12]1[O:11][C@@H:8]([CH2:7][N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)[CH2:9][O:10]1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 1268043HCID 1268043、化合物

生成物 1

HCID 86702828HCID 86702828、化合物収率 103%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of (2S)-3-(4-morpholinyl)-1,2-propanediol (0.90 g, 5.6 mmol) in CH2Cl2 (7.5 mL) was cooled to 0° C. and added thionyl chloride (0.81 mL, 11.1 mmol, 2.0 equiv.) was added dropwise. The resulting solution was heated at the reflux temperature for 1 hr, cooled to room temperature and concentrated under reduced pressure to give 4-[(4S)-(2-oxido-1,3,2-dioxathiolan-4-yl)methyl]morpholine hydrochloride (1.40 g, 103%). This material was used in the next step without further purification.

後処理

  1. additionwas added dropwise
  2. temperatureThe resulting solution was heated at the reflux temperature for 1 hr
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-7311380053744fec9529076764c10dd8
出典データセット
uspto-grants-2014_11
特許番号
US08895549B2

反応ノート

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