Butanedione → HCID 178432401、化合物

HRID 339799

反応式

HRID 339799 の反応式
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH2:8])[C:3]=1[NH2:9].CC(=O)C(=[O:14])C.[C:16]1(C)C=C[CH:19]=[CH:18][CH:17]=1>CO>[CH3:16][C:17]1[N:9]=[C:3]2[C:4](=[N:8][C:18]=1[CH3:19])[N:5]=[CH:6][N:7]=[C:2]2[OH:14]

参加物

5

反応物 3

HCID 650ButanedioneHCID 1140TolueneHCID 780104,5-Pyrimidinediamine, 6-chloro-

生成物 1

HCID 178432401HCID 178432401、化合物収率 72%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 6-chloropyrimidine-4,5-diamine (1.4 g, 10 mmol) and 2,3-butanedione (2.0 g, 23 mmol) in toluene (35 mL) and methanol (10 mL) was stirred at reflux for 1 h. Upon cooling, the product precipitated and was collected by suction filtration and rinsed with a MeOH/Et2O mixture (ca. 1:2), then air dried to afford 6,7-dimethylpteridin-4-ol (1.4 g, 72%) as a gold powder.

後処理

  1. temperatureat reflux for 1 h
  2. temperatureUpon cooling
  3. customthe product precipitated
  4. filtrationwas collected by suction filtration
  5. washrinsed with a MeOH/Et2O mixture (ca. 1:2)
  6. customair dried

出典と根拠

ORDレコード
ord-cf819b3287c147ed84923bf362ed7613
出典データセット
uspto-grants-2014_11
特許番号
US08895568B2

関連ノート

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