Butanedione → HCID 178432401、化合物
反応式
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH2:8])[C:3]=1[NH2:9].CC(=O)C(=[O:14])C.[C:16]1(C)C=C[CH:19]=[CH:18][CH:17]=1>CO>[CH3:16][C:17]1[N:9]=[C:3]2[C:4](=[N:8][C:18]=1[CH3:19])[N:5]=[CH:6][N:7]=[C:2]2[OH:14]参加物
5
実験手順
A mixture of 6-chloropyrimidine-4,5-diamine (1.4 g, 10 mmol) and 2,3-butanedione (2.0 g, 23 mmol) in toluene (35 mL) and methanol (10 mL) was stirred at reflux for 1 h. Upon cooling, the product precipitated and was collected by suction filtration and rinsed with a MeOH/Et2O mixture (ca. 1:2), then air dried to afford 6,7-dimethylpteridin-4-ol (1.4 g, 72%) as a gold powder.
後処理
- temperatureat reflux for 1 h
- temperatureUpon cooling
- customthe product precipitated
- filtrationwas collected by suction filtration
- washrinsed with a MeOH/Et2O mixture (ca. 1:2)
- customair dried
出典と根拠
- ORDレコード
- ord-cf819b3287c147ed84923bf362ed7613
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08895568B2
反応ノート
読み込み中…