4-(Dimethylamino)phenyl isocyanate → HCID 178418433、化合物

HRID 3400

反応式

HRID 3400 の反応式
[CH2:1]([NH:6][CH2:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][NH:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[CH2:10][CH2:9]1)[CH2:2][CH2:3][CH2:4][CH3:5].[CH3:21][N:22]([CH3:32])[C:23]1[CH:28]=[CH:27][C:26]([N:29]=[C:30]=[O:31])=[CH:25][CH:24]=1>CCOCC.C(#N)C>[CH3:21][N:22]([CH3:32])[C:23]1[CH:28]=[CH:27][C:26]([NH:29][C:30](=[O:31])[N:15]([CH2:14][C@H:11]2[CH2:10][CH2:9][C@H:8]([CH2:7][N:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])[C:30]([NH:29][C:26]3[CH:27]=[CH:28][C:23]([N:22]([CH3:32])[CH3:21])=[CH:24][CH:25]=3)=[O:31])[CH2:13][CH2:12]2)[CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[CH:25][CH:24]=1

参加物

5

反応物 2

HCID 27333724-(Dimethylamino)phenyl isocyanateHCID 178418355HCID 178418355、化合物

生成物 1

HCID 178418433HCID 178418433、化合物収率 89%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6342Acetonitrile溶媒

実験手順

Trans-1,4-bis[(normalpentylamino)methyl]cyclohexane, 0.56 g, was dissolved in 10 ml of ether. A solution of 0.81 g of 4-dimethylaminophenyl isocyanate in 20 ml of acetonitrile was added. The reaction mixture was stirred at room temperature for 10 hours. The solvent of the reaction mixture was distilled off under reduced pressure and the residue was purified by silica gel column chromatography to provide 1.10 g (yield: 89%) of white crystals.

後処理

  1. distillationThe solvent of the reaction mixture was distilled off under reduced pressure
  2. customthe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-490d143774ec4390a10e9b0953bb6484
出典データセット
uspto-grants-1998_03
特許番号
US05733931

関連ノート

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