Water → 2-Bromo-5-fluoroanisole
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[OH:9].[C:10](=O)([O-])[O-].[K+].[K+].IC.O>CN(C)C=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[O:9][CH3:10]参加物
6
実験手順
10 g of 2-bromo-5-fluorophenol was dissolved in 105 mL of N,N-dimethylformamide, and added with 10.9 g of potassium carbonate and 4.9 mL of iodomethane under cooling, and stirred at room temperature for 3 hours. The reaction solution was added with water, extracted with diethyl ether, and the resultant organic layer was washed with saturated brine, and dried over magnesium sulfate. The solvent was evaporated, to afford 9.75 g of the title compound as a yellow oil.
後処理
- temperatureunder cooling
- extractionextracted with diethyl ether
- washthe resultant organic layer was washed with saturated brine
- dry with materialdried over magnesium sulfate
- customThe solvent was evaporated
出典と根拠
- ORDレコード
- ord-45cd9a0160cb412a851ecc8da71ed727
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07429609B2
反応ノート
読み込み中…